Preheat oven to 375 degrees F (190 degrees C). Grease 6 large muffin cups.
Stir flour, milk, and mayonnaise together in a bowl until smooth. Pour flour mixture into prepared muffin cups.
Bake until golden brown, about 30 minutes .
If you don’t have self-rising flour, you can substitute all-purpose flour, but you also add 1 1/2 teaspoon baking powder and a pinch of salt to flour before stirring in the milk and mayo.
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